Studies have shown that many people use natural remedies in order to treat a wide variety of diseases. While some of these treatments may be new in the scene; however, there is one remedy that has been around for thousands of years. The treatment is provided through herbal plant known as cannabis that grows naturally and is known for treating a wide variety of health conditions like arthritis, cancer, diabetes, leukemia, depression, insomnia, and many more. Besides the herbal plant, the liquid form is also known for its medical magic especially cannabis oil to treat cancer.
Knowing About Cannabis Oil
The herb cannabis is often used for its oil has a beneficial effect on the health of the people. Cannabis oil is extracted from the Cannabis Sativa plant by separating the resins from cannabis flowers with the help of a solvent extraction process.
The oil is a thick, sticky, resinous substance which is composed of cannabinoids like THC and CBD. Unlike Marijuana, it has got a low level of tetrahydrocannabinol (THC) chemical in it.
How Does It Help In Killing Cancer?
For every cell, there is a family of interconvertible sphingolipids that controls the life and death of the cells. Well, these profile factors are known as the ‘Sphingolipid Rheostat’. When the endogenous ceramide remains high, then the death of the cells is menacing. On the other hand, if ceramide level is low, the cell is strong.
Cannabinoid is regarded as a three dimensional molecule. There are two types of cannabinoid receptor sites CB1 and CB2. THC and anandamide activate the receptor sites. C. staiva strain of Cannabis is neuroactive; whereas C. indica is immuno-active. When THC gets connected to the CB1 or CB2 cannabinoid receptor site of the cancer cell, it raises the ceramide synthesis that leads to the death of cells. If a cell is normal and healthy, it won’t produce ceramide in the presence of THC. Therefore, it does not get affected by the cannabinoid.
Cancer cell dies not because of cytotoxic chemicals, but of a tiny shift in the mitochondria. The main role of the mitochondria is to produce energy. When ceramide begins to accumulate, thereby it starts to increase the pore permeability of the mitochondrial membrane to cytochrome C. As a result, cytochrome C gets pushed out of the mitochondria.
Ceramide can cause genotoxic stress on the cancer cell nucleus, thereby generating a protein p53. The job of this protein is to distort metabolism of calcium in the mitochondria. Ceramide also distorts the cellular lysosome, the digestive system of the cells. It actively stops the pro-survival pathways of the cells, leaving no chance for survival of the cancer cells.
CBD and THC are biomimetic to anandamide. So during stress or injury, when the body demands more than that can be produced by the body, the mimetic endocannabinoids gets activated. Hence, during cancer when the treatment requires the need of sustained pressure of the modulating agent on the homeostatic systems.
Basically, THC moves to the CB2 receptors in the spleen which is the immune system. The immune system then destroys the cancer cells. However, THC and CBD can directly attack the cancer cells by stopping the growth of the tumor.